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Written for an introductory course in cell and molecular biology, this text elaborates on fundamental concepts, such as the relationship between molecular structure and function, the use of chemical energy in operating cellular activities, and the observed unity and diversity at macromolecular and cellular levels.

This Seventh Edition connects experimental material to key concepts of Cell Biology. The text offers streamlined information that reinforces a connection of key concepts to experimentation. Though the use paired art, and new science illustrations, readers benefit from a visual representation of experimental connections. Animations and video clips are tied to key illustrations with practice questions to provide a variety of ways to experience a key concept. This new edition offers an appropriate balance of concepts and experimentation. Experimental detail is offered when it helps to reinforce the concept being explained.

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1 Introduction to Cell Biology 1
1.1 The Discovery of Cells 2
1.2 Basic Properties of Cells 3
1.3 Two Fundamentally Different Classes of Cells 7
1.4 Viruses 23
2 The Structure and Functions of Biological Molecules 32
2.1 Covalent Bonds 33
2.2 Noncovalent Bonds 34
2.3 Acids, Bases, and Buffers 39
2.4 The Nature of Biological Molecules 40
2.5 Four Types of Biological Molecules 42
4.5 The Stability of the Genome 140
4.6 Sequencing Genomes: The Footprints of Biological Evolution 145
5 The Path to Gene Expression 160
5.1 The Relationship between Genes, Proteins, and RNAs 161
5.2 An Overview of Transcription in Both Prokaryotic and Eukaryotic Cells 163
5.3 Synthesis and Processing of Eukaryotic Ribosomal and Transfer RNAs 169
5.4 Synthesis and Processing of Eukaryotic Messenger RNAs 175
5.5 Small Regulatory RNAs and RNA Silencing Pathways 189
5.6 Encoding Genetic Information 195
5.7 Decoding the Codons: The Role of Transfer RNAs 198
5.8 Translating Genetic Information 202
6 Controlling Gene Expression 217
6.1 Control of Gene Expression in Bacteria 218
6.2 Control of Gene Expression in Eukaryotes: Structure and Function of the Cell Nucleus 222
6.3 An Overview of Gene Regulation in Eukaryotes 246
6.4 Transcriptional Control 248
6.5 RNA Processing Control 267
6.6 Translational Control 270
6.7 Posttranslational Control: Determining Protein Stability 275
7 Replicating and Repairing DNA 279
7.1 DNA Replication 280
7.2 DNA Repair 298
7.3 Between Replication and Repair 302
8 Cellular Membranes 306
8.1 An Overview of Membrane Functions 307
8.2 A Brief History of Studies on Plasma Membrane Structure 309
8.3 The Chemical Composition of Membranes 311
8.4 The Structure and Functions of Membrane Proteins 316
8.5 Membrane Lipids and Membrane Fluidity 324
8.6 The Dynamic Nature of the Plasma Membrane 326
8.7 The Movement of Substances Across Cell Membranes 333
8.8 Membrane Potentials and Nerve Impulses 350
9 Mitochondrial Structure and Function 364
9.1 Mitochondrial Structure and Function 365
9.2 Oxidative Metabolism in the Mitochondrion 369
9.3 The Role of Mitochondria in the Formation of ATP 375
9.4 Translocation of Protons and the Establishment of a Proton-Motive Force 384
9.5 The Machinery for ATP Formation 385
9.6 Peroxisomes 39210 Chloroplast Structure and Function 397
10.1 Chloroplast Structure and Function 399
10.2 An Overview of Photosynthetic Metabolism 400
10.3 The Absorption of Light 402
10.4 Photosynthetic Units and Reaction Centers 404
10.5 Photophosphorylation 411
10.6 Carbon Dioxide Fixation and the Synthesis of Carbohydrate 412
11 The Extracellular Matrix and Cell Interactions 421
11.1 The Extracellular Space 422
11.2 Interactions of Cells with Extracellular Materials 430
11.3 Interactions of Cells with Other Cells 436
11.4 Tight Junctions: Sealing The Extracellular Space 446
11.5 Gap Junctions and Plasmodesmata: Mediating Intercellular Communication 448
11.6 Cell Walls 452
12 Cellular Organelles and Membrane Trafficking 456
12.1 An Overview of the Endomembrane System 457
12.2 A Few Approaches to the Study of Endomembranes 459
12.3 The Endoplasmic Reticulum 465
12.4 The Golgi Complex 476
12.5 Types of Vesicle Transport and Their Functions 481
12.6 Lysosomes 489
12.7 Plant Cell Vacuoles 493
12.8 The Endocytic Pathway: Moving Membrane and Materials into the Cell Interior 494
12.9 Posttranslational Uptake of Proteins by Peroxisomes, Mitochondria, and Chloroplasts 502
13 The Cytoskeleton 510
13.1 Overview of the Major Functions of the Cytoskeleton 511
13.2 The Study of the Cytoskeleton 512
13.3 Microtubules 516
13.4 Intermediate Filaments 540
13.5 Microfilaments 542
13.6 Muscle Contractility 550
13.7 Nonmuscle Motility 557
14 Cell Division 572
14.1 The Cell Cycle 573
14.2 M Phase: Mitosis and Cytokinesis 581
14.3 Meiosis 602
15 Cell Signaling Pathways 617
15.1 The Basic Elements of Cell Signaling Systems 618
15.2 A Survey of Extracellular Messengers

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