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This volume focuses on apoptotic and non-apoptotic programmed cell death, including necroptosis, pyroptosis, and ferroptosis, and presents recent findings in the field. It discusses the crucial role that apoptotic and non-apoptotic cell death play in various pathological conditions, such as skin diseases, inflammatory bowel diseases, and virus infections. Further, it highlights the mechanisms underlying the recognition and clearance of dead cells, and the subsequent biological responses triggered by phagocytosed macrophages and factors released from dying cells. Offering insights into cell death, it is a valuable resource for researchers and clinicians developing novel strategies to treat various diseases that are closely associated with cell death.

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This volume focuses on apoptotic and non-apoptotic programmed cell death, including necroptosis, pyroptosis, and ferroptosis, and presents recent findings in the field. It discusses the crucial role that apoptotic and non-apoptotic cell death play in various pathological conditions, such as skin diseases, inflammatory bowel diseases, and virus infections. Further, it highlights the mechanisms underlying the recognition and clearance of dead cells, and the subsequent biological responses triggered by phagocytosed macrophages and factors released from dying cells. Offering insights into cell death, it is a valuable resource for researchers and clinicians developing novel strategies to treat various diseases that are closely associated with cell death.

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Intro -- Preface -- Contents -- 467 Prix Fixe: Efferocytosis as a Four-Course Meal -- Abstract -- 1 Introduction -- 2 Prepping of the Meal: Types of Cell Death -- 2.1 Apoptosis -- 2.2 Necrosis -- 2.3 Necroptosis -- 2.4 Pyroptosis -- 3 The Dining Experience: The Mechanisms of Efferocytosis -- 3.1 Perusing the Menu: “Find-Me” Signals -- 3.2 It is All in the Presentation: “Eat-Me” Signals -- 3.3 Savoring the Meal: Phagocytosis of Cellular Corpses -- 3.4 Aperitifs and Digestifs: Digestion and Immune Response -- 4 Food Poisoning: Pathologies Associated with Aberrant Efferocytosis -- 4.1 Systemic Lupus Erythematosus (SLE) -- 4.2 Rheumatoid Arthritis -- 4.3 Type 1 Diabetes -- 4.4 Atherosclerosis -- 4.5 Lung Inflammation -- 4.6 Neurodegenerative Disorders -- 5 Conclusions -- References -- 449 Emerging Roles for RIPK1 and RIPK3 in Pathogen-Induced Cell Death and Host Immunity -- Abstract -- 1 Introduction -- 2 Pathogen-Induced Cell Death -- 2.1 Viral-Induced Cell Death -- 2.1.1 HSV -- 2.1.2 CMV -- 2.1.3 Reoviruses -- 2.1.4 Influenza A -- 2.2 Bacterial-Induced Cell Death -- 2.2.1 Yersinia -- 2.2.2 Salmonella -- 2.2.3 Escherichia Coli -- 2.2.4 Pore-Forming Toxin-Producing Bacteria -- 2.2.5 Mycobacterium Tuberculosis -- 2.3 Summary -- 3 Epithelial Barrier Function -- 3.1 Intestinal Epithelia -- 3.1.1 Kinase-Independent Functions of RIPK1 -- 3.1.2 Kinase-Dependent Regulation by RIPK1 and the Role of RIPK3 -- 3.2 Skin -- 3.2.1 Kinase-Independent Functions of RIPK1 -- 3.2.2 The Role of RIPK3 -- 3.3 Summary -- 4 Inflammation -- 4.1 RIPK1 -- 4.2 Kinase-Dependent Inflammatory Functions of RIPK1 -- 4.3 RIPK3 -- 4.4 Summary -- 5 RIPK1 and RIPK3 as Therapeutic Targets in Light of New Innate Immune Roles -- 6 Discussion -- References -- 466 Epithelial Cell Death and Inflammation in Skin -- Abstract -- 1 Introduction -- 1.1 The Skin Epithelium -- 1.2 NF-κB Signaling -- 1.3 Regulated Cell Death: Apoptosis and Necroptosis -- 1.4 TNFR1 Signaling -- 2 Inflammatory and Cell Death Signaling in Skin Homeostasis: Lessons from Mouse Models -- 2.1 NF-κB Signaling in Keratinocytes Controls Skin Homeostasis and Inflammation -- 2.2 FADD/Caspase-8 in Epithelial Cells Prevent Necroptosis and Inflammation -- 2.3 CFLIP Contributes to Epidermal Homeostasis -- 2.4 RIP Kinase 1 Protects Necroptosis of Keratinocytes -- 2.5 SHARPIN Inhibits Keratinocytes Apoptosis -- 3 Conclusion and Perspectives -- Acknowledgments -- References -- 507 IAPs and Cell Death -- Abstract -- 1 Introduction -- 2 IAPs and Apoptosis -- 2.1 The Very Beginning—How IAPs Were Discovered -- 2.2 XIAP Inhibiting Apoptosis -- 2.3 Different Hypotheses to Explain What XIAP Is Doing -- 3 IAPs Regulate Signalling and the Intersection with Cell Death -- 4 IAPs and Necroptosis -- 5 IAPs and Pyroptosis -- 6 Conclusion -- References -- 448 Cellular FLICE-Inhibitory Protein Regulates Tissue Homeostasis -- Abstract -- 1 Introduction -- 2 Structure and Function of cFLIP -- 3 cFLIP Regulates Necroptosis -- 4 Regulation of Expression of cFLIP -- 5 Other Signaling Pathways Regulated by cFLIP -- 5.1 cFLIP and the NF-κB Pathway -- 5.2 cFLIP and the MAPK Pathway -- 5.3 cFLIP and the Wnt Pathway -- 6 cFLIP Plays a Crucial Role in Tissue Homeostasis -- 6.1 Germline Deletion of Cflip Results in Embryonic Lethality Due to Enhanced Apoptosis and Necroptosis -- 6.2 Roles for cFLIP in Immune Cells -- 6.3 Roles for cFLIP in Intestinal Epithelial Cells -- 6.4 Roles for cFLIP in Epidermis -- 6.5 Roles for cFLIP in Hepatocytes -- 7 Transgenic Expression of CFLIPL and CFLIPs in T Cells Exhibits Relatively Mild Phenotypes -- 8 Roles for cFLIP in the Development of Human Diseases -- 9 Is Oxidative Stress Involved in Necroptosis? -- 9.1 Cellular Sources of ROS Responsible for Necroptosis -- 9.2 Contribution of ROS and Mitochondria to Necroptosis -- 10 Conclusions -- Acknowledgments -- References -- 508 Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis -- Abstract -- 1 Introduction -- 2 Structure and Expression of Three Types of Organelle-Specific GPx4 -- 3 Function of Three Types of Organelle-Specific GPx4 in Cells -- 4 Mitochondrial GPx4 Inhibit the Release of cyt.c from Mitochondria by Cardiolipin Hydroperoxide in Apoptosis by Mitochondrial Death Pathway -- 5 Suppression of Peroxidation of Phospholipid by Non-mitochondrial GPx4 and Vitamin E Is Essential for the Survival of Cells and Mice -- 6 Ferroptosis by Oncogenic Mutated Ras-Selective Lethal Compounds -- 6.1 Inhibition of System Xc− Leads to Ferroptosis (Type I) -- 6.2 Inhibition of Chemical Inactivation of GPx4 Leads to Ferroptosis (Type II) -- 6.3 The Role of Iron Homeostasis in Ferroptosis -- 6.4 Regulation of Phospholipid Peroxidation Modulate the Sensitivity of Ferroptosis -- 7 Lipid Peroxidation-Dependent Cell Death by GPx4 Gene Disruption -- 8 Ferroptosis in Disease Model -- 9 Conclusion and Prospective -- Acknowledgements -- References -- 472 Immune Regulation by Dead Cell Clearance -- Abstract -- 1 Introduction -- 2 Phagocytosis of Dead Cells by Macrophages -- 3 Apoptotic Cell Clearance in Living Organisms -- 4 Subset of Macrophages Responsible for Phagocytosis of Apoptotic Cells -- 5 Dead Cell-Derived Substances and Their Roles in Macrophage Activation and Regeneration -- 6 Apoptosis and Non-apoptotic Cell Death in Vivo -- 7 Conclusion -- Acknowledgments -- References -- .