상세정보

This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively

정보제공 :

[Volume. 1]----------
CONTENTS
Chapter 1 Basic Principles of Target Organ Toxicity / Gerald M. Cohen = 1
 Ⅰ. Introduction = 2
  A. Factors Affecting Toxicity = 2
 Ⅱ. Disposition of the Toxic Chemical = 2
  A. Binding to a Specific Macromolecule : Melanin = 5
 Ⅲ. Role of Metabolic Activation in Target Organ Toxicity = 5
  A. Toxicity Mediated by the Parent Compound = 5
  B. Toxicity Mediated by Reactive Metabolites = 5
  C. Tissue Distribution of Xenobiotic Metabolizing Enzymes = 7
  D. Balance of Activating and Deactivating Enzymes = 8
  E. Formation of Proximate Toxic Metabolites in the Liver and Ultimate Reactive Metabolites in the Target Tissue = 9
 Ⅳ. Role of the Specific Biochemistry or Physiology of the Tissue in Determining Target Organ Toxicity = 10
  A. Organ Function = 10
  B. Organ-Specific Biochemistry = 10
 Ⅴ. Factors Affecting Target Organ Toxicity = 11
 Ⅵ. Summary = 11
 Acknowledgment = 11
 References = 14
Chapter 2 Role of Pharmacokinetics in Rationalizing Tissue Distribution / J. Brian Houston = 17
Chapter 3 The Role of Metabolic Activation in Target Organ Toxicity / John Caldwell ; Susan A. Sangster ; J. David Sutton = 37
Chapter 4 Role of Excretion / Walter G. Levine = 55
Chapter 5 Species Variation in Target Organ Toxicity / J. C. Connelly ; James W. Bridges = 89
Chapter 6 The Importance of Tissue-Specific Biochemistry in the Determination of Target Organ Toxicity / Steven D. Aust = 121
Chapter 7 Role of Key Defense Systems in Target Organ Toxicity / Toshihisa Ishikawa ; Theodorus P. M. Akerboom ; Helmut Sies = 129
Chapter 8 The Liver as a Target Organ for Toxicity / J. A. Timbrell = 145
Chapter 9 The Nervous System as a Target Organ for Toxicity / Rebecca J. Anderson ; Rudy J. Richardson ; Bradley W. Schwab = 175
Index = 203
[Volume. 2]----------
CONTENTS
Chapter 1 The Kidney as a Target Organ for Toxicity / Glenn F. Rush ; Jerry B. Hook = 1
 Ⅰ. Introduction = 2
  A. Anatomy = 2
  B. Unique Susceptibility of the Kidney to Toxicants = 2
 Ⅱ. Susceptibility of the Glomerulus to Toxicants = 3
  A. Introduction = 3
  B. The Glomerulus as a Target for Toxicity = 4
   1. Immune-Mediated Glomerular Nephritis Involving Soluble Antigens = 4
   2. Aminoglycoside-Induced Glomerular Toxicity = 6
 Ⅲ. Susceptibility of the Proximal Tubule to Toxicants = 6
  A. Introduction = 6
  B. The Proximal Tubule as a Target for Toxicity = 7
   1. Cephalosporin Nephrotoxicity = 7
   2. Aminoglycoside-induced Proximal Tubular Damage = 9
   3. Proximal Tubular Damage from Cysteine Conjugates of Halogenated Hydrocarbons = 9
   4. Cadmium Nephropathy = 10
 Ⅳ. Susceptibility of the Renal Medulla to Toxicants = 11
  A. Introduction = 11
  B. The Renal Medulla as a Target for Toxicity = 11
   1. Fluoride Nephropathy = 11
   2. 2-Bromoethylamine Hydrobromide-Induced Papillary Necrosis = 13
 Ⅴ. Susceptibility of the Distal Nephron to Toxicants = 13
  A. Introduction = 13
  B. The Distal Nephron as a Target for Nephrotoxicants = 14
   1. Tetracycline Nephrotoxicity = 14
 References = 15
Chapter 2 Cardiac Toxicity / T. Balazs ; Victor J. Ferrans ; Joseph P. Hanig ; Eugene Herman = 19
Chapter 3 The Lung as a Target Organ for Toxicity / Lewis L. Smith ; Benoit Nemery = 45
Chapter 4 Target Organ Toxicity : The Male Reproductive System / H. D. M. Moore = 81
Chapter 5 Toxic Effects on the Female Reproductive System / Michael H. Briggs = 97
Chapter 6 The Eye / Ralph Heywood = 109
Chapter 7 The Inner Ear / Ernest S. Harpur = 125
Chapter 8 The Endocrine Pancreas as a Target Organ for Toxicity / Willy J. Malaisse = 143
Chapter 9 Structural DNA Modifications and DNA Repair in Organ-Specific Tumor Induction / P. Kleihues ; Otmar Wiestler = 159
Chapter 10 Organ Specificity in Tumor Initiation and Comple Carcinogenesis(Including Species Variation) / Maurice M. Coombs = 181
Index = 209