상세정보

In response to the field's need for an introductory text, the authors have distilled the vast and scattered literature relating to the biotechnology of microbial secondary metabolites. General biology, biosynthesis, the search for novel metabolites, and techniques for strain improvement are all discussed to provide undergraduate and graduate students with a concise, readable overview of the field.

In response to the field's need for an introductory text, the authors have distilled the vast and scattered literature relating to the biotechnology of microbial secondary metabolites. General biology, biosynthesis, the search for novel metabolites, and techniques for strain improvement are all discussed to provide undergraduate and graduate students with a concise, readable overview of the field.

정보제공 :

목차
1. Antibiotics and Bioactive Microbial Metabolites = 1
 1.1 Antibiotics = 1
 1.2 Bioactive Secndray Metabilites = 10
2. Biology of Antibiotic-Producing Mcroorganisms = 19
 2.1 Genus Bacillus = 19
 2.2 Genus Preudomonas = 25
 2.3 Streptomyces and Streptoverticillium = 29
 2.4 Genera of Actinomycetales Other Than Streptomyces = 49
 2.5 The Myxobacteria = 57
 2.6 Genus Aspergillus = 60
 2.7 Genus Penicillium = 64
 2.8 Genera Producing a Few Interesting Metabolites = 68
3. The Search for New Bioactive Microbial Metabolites = 73
 3.1 Basic Screening Methodologies = 73
 3.2 Improving Screening Efficiency : Selection of Producing Organisms = 76
 3.3 Improving Screening Efficiency : Innovative Activity Tests = 80
 3.4 Screening Efficiency : Quantitative and Organization Aspects = 89
4. Biosynthesis of Secondary Metabolites = 95
 4.1 Methods of Study = 95
 4.2 Biosynthetic Reactions and Pathways = 99
 4.3 Class Ⅰ Reactions : Transformation of Primary Metabolites into Biosynthetic Intermediates = 101
 4.4 Class Ⅱ Reactions : Polymerization of Small MetaBolites = 111
 4.5 Class Ⅲ Reactions : Modifications of the Basic Structure = 127
5. Reaulation of Antibiotic Biosynthesis = 133
 5.1 Feedback Regulation = 133
 5.2 Regulation by Nutrient Concentration = 134
 5.3 Autoregulators and Pleiotropic Effectors = 141
6. Genetics of Antibiotic Production = 145
 6.1 Introduction = 145
 6.2 Genes for Self-resistance = 151
 6.3 Regulatory Genes = 155
 6.4 Structural Biosynthetic Genes = 160
7. Strain Improvement and Process Development = 175
 7.1 Strain Purification and Natural Variants = 176
 7.2 Mutation and Selection = 176
 7.3 Gene Recombination = 182
 7.4 Process Development = 186
8. Biological Transformations = 191
 8.1 Precursor-Directed Biosynthesis = 191
 8.2 Genetic and Molecular Biology Methods = 198
 8.3 Screening of Microorganisms for Specific Transformation Reactions = 203
 8.4 Enzymatic Synthesis of New -Lactams = 208
9. Production of Secondary Metabolites = 215
 9.1 Strain Maintenance and Prservation = 215
 9.2 Fermentation Technology = 216
 9.3 The Process = 219
Index = 227