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When looking for a book on fish toxicology, you might find one that discusses the biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You can find resources that cover human and animal toxicology or ecotoxicology in general, but no up-to-date, comprehensive monograph devoted to the effects of chemical pollution on these organisms has been widely available, until now. Filling this void, The Toxicology of Fishes, written by recognized experts, covers toxic responses ranging from reduced reproduction and/or abnormal development, growth, and differentiation.

General Principles ? Discusses fundamental topics such as the bioavailability of chemicals present in the aquatic environment to fishes, processes governing chemical distribution within these organisms, how fish metabolize organic chemicals, and fundamental mechanisms of chemical toxicity

Key Target Systems and Organismal Effects ? Describes key target organ systems for chemical impacts in fish, how chemicals produce cancer in these animals, and how fishes can develop resistance to chemical toxicity

Methodologies and Applications ? Dovers methods for the assessment of chemical effects on fish such as toxicity tests, biomarkers, simulated ecosystems, and modeling approaches and the use of data from such studies in ecological risk assessments

Case Studies ? Provides examples of how the principles and approaches presented in earlier units are actually deployed in studies

Illustrated by case studies of actual, large-scale field investigations, the book reviews the tools used to assess unwanted effects in laboratory model- and wild fish in detail. With 238 illustrations, 70 tables, and 50 equations, this comprehensive monograph presents detailed information on the boiavailability of chemical pollutants, their distribution, metabolism, and excretion in the host fish and mechanisms and sites of toxic responses.

An in-depth, state-of-the-science monograph on the interactions of chemical contaminants with freshwater and marine fishes, this book discusses critical general principles, such as bioaccumulation, toxicokinetics, biotransformations, mechanisms of toxic action, and adaptations to chemical stress and key target systems of fishes, such as liver, kidney, gills, nervous and immune systems, and reproduction. It also covers methodologies and applications for exposure, assessment, toxicity testing, and ecological studies and includes case studies that illustrate the toxicological impacts of important classes of chemical contaminants in real-world settings.

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General Principles
  
Introduction, R.T. Di Giulio and D.E. Hinton  
Bioavailability of Chemical Contaminants in Aquatic Systems, R.J. Erickson, J.W. Nichols, P.M. Cook, and G.T. Ankley  
Toxicokinetics in Fishes, K.M. Kleinow, J.W. Nichols, W.L. Hayton, J.M. McKim, and M.G. Barron  
Biotransformation in Fishes, D. Schlenk, M. Celander, E.P. Gallagher, S. George, M. James, S.W. Kullman, P. van den Hurk, and K. Willett  
Receptor-Mediated Mechanisms of Toxicity, M.E. Hahn and E.V. Hestermann  
Reactive Oxygen Species and Oxidative Stress, R.T. Di Giulio and J.N. Meyer    
Key Target Systems and Organismal Effects
  
Liver Toxicity, D.E. Hinton, H. Segner, D.W.T. Au, S.W. Kullman, and R.C. Hardman  
The Osmoregulatory System, S.E. Wendelaar Bonga and R.A.C. Lock  
Toxic Responses of the Fish Nervous System, S.P. Bradbury, R.W. Carlson, T.R. Henry, S. Padilla, and J. Cowden  
The Endocrine System, P. Thomas  
The Immune System of Fish: A Target Organ of Toxicity, E. Carlson and J.T. Zelikoff  
Chemical Carcinogenesis in Fishes, J.M. Rotchell, M.R. Miller, D.E. Hinton, R.T. Di Giulio, and G.K. Ostrander  
Toxicity Resistance, P.A. Van Veld and D.E. Nacci    
Methodologies and Applications
  
Exposure Assessment and Modeling in the Aquatic Environment, D. Mackay and L. Milford  
Fish Toxicity Studies, G.M. Rand  
Biomarkers, D. Schlenk, R. Handy, S. Steinert, M.H. Depledge, and W. Benson  
Aquatic Ecosystems for Ecotoxicological Research: Considerations in Design Analysis for Fish, T.W. La Point, J.H. Kennedy, J.K. Stanley, and P. Balci  
Ecological Risk Assessment, D.R. Mount and T.R. Henry    
Case Studies
  
Mining Impacts on Fish in the Clark Fork River, Montana: A Field Ecotoxicology Case Study, S.N. Luoma, J.N. Moore, A. Farag, T.H. Hillman, D.J. Cain, and M. Hornberger  
Toxicology of Synthetic Pyrethroid Insecticides in Fish: A Case Study, J.R. Coats  
Reproductive Impairment of Great Lakes Lake Trout by Dioxin-Like Chemicals, D.E. Tillitt, P.M. Cook, J.P. Giesy, W. Heideman, and R.E. Peterson  
The Effects of Polycyclic Aromatic Hydrocarbons in Fish from Puget Sound, Washington, L.L. Johnson, M.R. Arkoosh, C.F. Bravo, T.K. Collier, M.M. Krahn, J.P. Meador, M.S. Myers, W.L. Reichert, and J.E. Stein  
Effects of the Exxon Valdez Oil Spill on Pacific Herring in Prince William Sound, Alaska, G.D. Marty  
Case Study: Pulp and Paper Mill Impacts, M.G. Dube, K.R. Munkittrick, and L.M. Hewitt  
Estrogenic Effects of Treated Sewage Effluent on Fish: Steroids and Surfactants in English Rivers, C.R. Tyler, E.J. Routledge, and R. van Aerle  
Index

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