| 000 | 03872camuu2200385 a 4500 | |
| 001 | 000045770694 | |
| 005 | 20131021220847 | |
| 008 | 131021s2013 nyua b 001 0 eng | |
| 020 | ▼a 9781627035286 | |
| 020 | ▼a 9781627035293 (electronic bk.) | |
| 020 | ▼a 162703529X (electronic bk.) | |
| 040 | ▼a GW5XE ▼e rda ▼e pn ▼c GW5XE ▼d CDX ▼d SCB ▼d COO ▼d KUB ▼d 211009 | |
| 050 | 4 | ▼a RA1224.3 |
| 060 | 4 | ▼a QU 550.5 M8 ▼b G335 2013 |
| 082 | 0 4 | ▼a 615.9 ▼2 23 |
| 084 | ▼a 615.9 ▼2 DDCK | |
| 090 | ▼a 615.9 ▼b G335 | |
| 245 | 0 0 | ▼a Genotoxicity assessment : ▼b methods and protocols / ▼c edited by Alok Shawan, Mahima Bajpayee. |
| 260 | ▼a New York : ▼b Humana Press : ▼b Springer, ▼c 2013. | |
| 300 | ▼a xv, 463 p. : ▼b ill. (some col.) ; ▼c 27 cm. | |
| 490 | 1 | ▼a Methods in molecular biology, ▼x 1064-3745 ; ▼v 1044 |
| 490 | 1 | ▼a Springer protocols |
| 504 | ▼a Includes bibliographical references and index. | |
| 505 | 0 0 | ▼t Bacterial mutation assays / ▼r Zeiger, Errol -- ▼t In vitro mouse lymphoma (L5178Y Tk+/- -3.7.2C) forward mutation assay / ▼r Schisler, Melissa R., ▼r Moore, Martha M., ▼r Gollapudi, B. Bhaskar -- ▼t Erythrocyte-based pig-a gene mutation assay / ▼r Bemis, Jeffrey C., ▼r Hall, Nikki E., ▼r Dertinger, Stephen D. -- ▼t Detection of in vivo mutation in the Hprt and pig-a genes of rat lymphocytes / ▼r Dobrovolsky, Vasily N. ... [et al.] -- ▼t In vivo cII, gpt, and spi- gene mutation assays in transgenic mice and rats / ▼r Manjanatha, Mugimane G. ... [et al.] -- ▼t In vitro cytogenetic assays : chromosomal aberrations and micronucleus tests / ▼r Laubenthal, Julian ... [et al.] -- ▼t Comet assay : assessment of in vitro and in vivo DNA damage / ▼r Bajpayee, Mahima, ▼r Kumar, Ashutosh, ▼r Dhawan, Alok -- ▼t Comet assay in human biomonitoring / ▼r Anderson, Diana, ▼r Dhawan, Alok, ▼r Laubenthal, Julian -- ▼t Comet assay in marine animals / ▼r Frenzilli, Giada, ▼r Lyons, Brett P. -- ▼t Unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo / ▼r Nesslany, Fabrice -- ▼t 32P-postlabeling analysis of DNA adducts / ▼r Schmeiser, Heinz H., ▼r Stiborova, Marie, ▼r Arlt, Volker M. -- ▼t Micronucleus assay with tetrad cells of tradescantia / ▼r Misik, Miroslav ... [et al.] -- ▼t Wing-spot and the comet tests as useful assays detecting genotoxicity in Drosophila / ▼r Marcos, Ricard, ▼r Carmona, Erico R. -- ▼t Genotoxicity guidelines recommended by International Conference of Harmonization (ICH) / ▼r Kamath, Gireesh H., ▼r Rao, K. S. |
| 520 | ▼a Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals.In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetictoxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successfulMethods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips ontroubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences. | |
| 650 | 0 | ▼a Genetic toxicology ▼v Laboratory manuals. |
| 650 | 2 | ▼a Mutation ▼x genetics. |
| 650 | 2 | ▼a Genetic Testing. |
| 650 | 2 | ▼a Molecular Diagnostic Techniques. |
| 700 | 1 | ▼a Dhawan, Alok. |
| 700 | 1 | ▼a Bajpayee, Mahima. |
| 830 | 0 | ▼a Methods in molecular biology (Clifton, N.J.) ; ▼v v. 1044. |
| 830 | 0 | ▼a Springer protocols. |
| 945 | ▼a KLPA |
소장정보
| No. | 소장처 | 청구기호 | 등록번호 | 도서상태 | 반납예정일 | 예약 | 서비스 |
|---|---|---|---|---|---|---|---|
| No. 1 | 소장처 과학도서관/Sci-Info(2층서고)/ | 청구기호 615.9 G335 | 등록번호 121226897 (1회 대출) | 도서상태 대출가능 | 반납예정일 | 예약 | 서비스 |
컨텐츠정보
책소개
Part I: Gene Mutation Assays
1. Bacterial Mutation Assays
Errol Zeiger
2. In Vitro Mouse Lymphoma (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay
Melissa R. Schisler, Martha M. Moore, and B. Bhaskar Gollapudi
3. Erythrocyte--Based Pig--a Gene Mutation Assay
Jeffrey C. Bemis, Nikki E. Hall, and Stephen D. Dertinger
4. Detection of in vivo Mutation in the Hprt and Pig--a Genes of Rat Lymphocytes
Vasily N. Dobrovolsky, Joseph G. Shaddock, Roberta A. Mittelstaedt, Daishiro Miura, and Robert H. Heflich
5. In vivo cII, gpt, and Spi- gene Mutation Assays in Transgenic Mice and Rats
Mugimane G. Manjanatha, Xuefei Cao, Sharon D. Shelton, Roberta A. Mittelstaedt, and Robert H. Heflich
Part II; Assays for Chromosomal Abnormalities
6. In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests
Pasquale Mosesso, Serena Cinelli, Adyapalam T. Natarajan, and Fabrizio Palitti
7. Analysis of Chromosome Aberrations in Somatic and Germ Cells of the Mouse
Francesca Pacchierotti and Valentina Stocchi
8. Chromosomal Aberration Test in Human Lymphocytes
Christian Johannes and Guenter Obe
9. In vivo Micronucleus Assay in Mouse Bone Marrow and Peripheral Blood
Sawako Kasamoto, Shoji Masumori, and Makoto Hayashi
10. Micronucleus Assay in Human Cells: Lymphocytes and Buccal Cells
Claudia Bolognesi and Michael Fenech
11. Flow Cytometric Determination of Micronucleus Frequency
Azeddine Elhajouji and Magdalena Lukamowicz-Rajska
12. Fluorescent in situ Hybridization (FISH) Technique for the Micronucleus Test
Ilse Decordier and Micheline Kirsch-Volders
13. Comparative Genomic Hybridization (CGH) Genotoxicology
Baumgartner A
14. The in vitro Micronucleus Assay and Kinetochore Staining: Methodology and Criteria for the Accurate Assessment of Genotoxicity and Cytotoxicity
Bella B. Manshian, Neenu Singh, and Shareen H. Doak
Part III: Tests for Primary DNA Damage
15. g--H2AX Detection in Somatic and Germ Cells of Mice
Eugenia Cordelli and Lorena Paris
16. Multicolour Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers
Julian Laubenthal, Michal R. Gdula, Alok Dhawan, and Diana Anderson
17. The Comet Assay: Assessment of in vitro and in vivo DNA Damage
Mahima Bajpayee, Ashutosh Kumar, and Alok Dhawan
18. The Comet Assay in Human Biomonitoring
Diana Anderson, Alok Dhawan, and Julian Laubenthal
19. The Comet assay in Marine Animals
G. Frenzilli and B.P. Lyons
20. Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo
Fabrice Nesslany
21. 32P--Postlabeling Analysis of DNA Adducts
Heinz H. Schmeiser, Marie Stiborova, and Volker M. Arlt
Part IV: Assays in Plants and Aleternate Animal Models
22. Micronucleus Assay with Tetrad Cells of Tradescantia
Miroslav Mis?k, Clemens Pichler, Bernhard Rainer, Armen Nersesyan, and Siegfried Knasmueller
23. The Wing--Spot and the Comet Tests as useful Assays Detecting Genotoxicity in Drosophila
Ricard Marcos and Erico R. Carmona
Part V: Guidelines
24. Genotoxicity Guidelines Recommended by International Conference of Harmonization (ICH)
Gireesh Kamath H. and K.S. Rao
정보제공 :
목차
Part I: Gene Mutation Assays 1. Bacterial Mutation Assays Errol Zeiger 2. In Vitro Mouse Lymphoma (L5178Y Tk +/- -3.7.2.C) Forward Mutation Assay Melissa R. Schisler, Martha M. Moore, and B. Bhaskar Gollapudi 3. Erythrocyte--Based Pig--a Gene Mutation Assay Jeffrey C. Bemis, Nikki E. Hall, and Stephen D. Dertinger 4. Detection of in vivo Mutation in the Hprt and Pig--a Genes of Rat Lymphocytes Vasily N. Dobrovolsky, Joseph G. Shaddock, Roberta A. Mittelstaedt, Daishiro Miura, and Robert H. Heflich 5. In vivo cII, gpt, and Spi - gene Mutation Assays in Transgenic Mice and Rats Mugimane G. Manjanatha, Xuefei Cao, Sharon D. Shelton, Roberta A. Mittelstaedt, and Robert H. Heflich Part II; Assays for Chromosomal Abnormalities 6. In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests Pasquale Mosesso, Serena Cinelli, Adyapalam T. Natarajan, and Fabrizio Palitti 7. Analysis of Chromosome Aberrations in Somatic and Germ Cells of the Mouse Francesca Pacchierotti and Valentina Stocchi 8. Chromosomal Aberration Test in Human Lymphocytes Christian Johannes and Guenter Obe 9. In vivo Micronucleus Assay in Mouse Bone Marrow and Peripheral Blood Sawako Kasamoto, Shoji Masumori, and Makoto Hayashi 10. Micronucleus Assay in Human Cells: Lymphocytes and Buccal Cells Claudia Bolognesi and Michael Fenech 11. Flow Cytometric Determination of Micronucleus Frequency Azeddine Elhajouji and Magdalena Lukamowicz-Rajska 12. Fluorescent in situ Hybridization (FISH) Technique for the Micronucleus Test Ilse Decordier and Micheline Kirsch-Volders 13. Comparative Genomic Hybridization (CGH) Genotoxicology Baumgartner A 14. The in vitro Micronucleus Assay and Kinetochore Staining: Methodology and Criteria for the Accurate Assessment of Genotoxicity and Cytotoxicity Bella B. Manshian, Neenu Singh, and Shareen H. Doak Part III: Tests for Primary DNA Damage 15. g--H2AX Detection in Somatic and Germ Cells of Mice Eugenia Cordelli and Lorena Paris 16. Multicolour Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers Julian Laubenthal, Michal R. Gdula , Alok Dhawan, and Diana Anderson 17. The Comet Assay: Assessment of in vitro and in vivo DNA Damage Mahima Bajpayee, Ashutosh Kumar, and Alok Dhawan 18. The Comet Assay in Human Biomonitoring Diana Anderson, Alok Dhawan, and Julian Laubenthal 19. The Comet assay in Marine Animals G. Frenzilli and B.P. Lyons 20. Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo Fabrice Nesslany 21. 32 P--Postlabeling Analysis of DNA Adducts Heinz H. Schmeiser, Marie Stiborova, and Volker M. Arlt Part IV: Assays in Plants and Aleternate Animal Models 22. Micronucleus Assay with Tetrad Cells of Tradescantia Miroslav Misik, Clemens Pichler, Bernhard Rainer, Armen Nersesyan, and Siegfried Knasmueller 23. The Wing--Spot and the Comet Tests as useful Assays Detecting Genotoxicity in Drosophila Ricard Marcos and Erico R. Carmona Part V: Guidelines 24. Genotoxicity Guidelines Recommended by International Conference of Harmonization (ICH) Gireesh Kamath H. and K.S. Rao
정보제공 :