상세정보

A reference on cellular signaling processes, the third edition of Signal Transduction continues in the tradition of previous editions, in providing a historical overview of how the concept of stimulus-response coupling arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, growth factors and adhesion molecules. In a new chapter, an introduction to signal transduction, the book provides a concise overview of receptor mechanisms, from receptor ? ligand interactions to post-translational modifications operational in the process of bringing about cellular changes. The phosphorylation process, from bacteria to men, is discussed in detail.

Signal transduction third edition further elaborates on diverse signaling cascades within particular contexts such as muscle contraction, innate and adaptive immunity, glucose metabolism, regulation of appetite, oncogenic transformation and cell fate decision during development or in stem cell niches. The subjects have been enriched with descriptions of the relevant anatomical, histological, physiological or pathological condition.

Feature

• In-depth insight into a subject central to cell biology and fundamental to biomedicine, including the search for novel therapeutic interventions
• Essential signaling events embedded in rich physiological and pathological contexts
• Extensive conceptual colour artwork to assist with comprehension of key topics
• Special emphasis on how molecular structure determines protein function and subcellular localization
• Employment of unambiguous protein names (symbols) in agreement with leading protein- and gene databases, allowing the learner to extend his/her exploration on the web

정보제공 :

Prologue : signal transduction from an historical perspective
An introduction to signal transduction
Regulation of muscle contraction by adrenoceptors
Cholinergic signaling and muscle contraction
Sensory signal processing; visual transduction and olfaction
Intracellular calcium
Bringing the signal into the nucleus : regulation of gene expression
Nuclear receptors
Protein kinase c in oncogenic transformation and cell polarity
Regulation of cell proliferation by receptor tyrosine protein kinases
Signal transduction to and from adhesion molecules
WNT signaling and the regulation of cell adhesion and differentiation
Activation of the innate immune system : the toll-like receptor-4 and signaling through ubiquitinylation
Chemokines and traffic of white blood cells
Activating the adaptive immune system : role of non-receptor tyrosine kinases
Signaling through the insulin receptor : phosphoinositide 3-kinases and AKT
TGF[beta] and signaling through receptor serine/threonine protein kinases
Protein phosphatases
Cell fate determination by notch.