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Looking to the future, the editors predict that the foundational information provided in this book -- combined with the advent of new tools and budding interests in use of non-rodent mammalian models -- will produce another major advance in knowledge regarding the biology of spermatogonia over the next decade. In particular, we anticipate that the core molecular machinery driving different spermatogonial states in most, if not all, mammals will be described fully, the extrinsic signals emanating from somatic support cell populations to influence spermatogonial functions will become fully known, and the capacity to derive long-term cultures of SSCs and transplant the population to regenerate spermatogenesis and fertility will become a reality for higher order mammals.

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Looking to the future, the editors predict that the foundational information provided in this book -- combined with the advent of new tools and budding interests in use of non-rodent mammalian models -- will produce another major advance in knowledge regarding the biology of spermatogonia over the next decade. In particular, we anticipate that the core molecular machinery driving different spermatogonial states in most, if not all, mammals will be described fully, the extrinsic signals emanating from somatic support cell populations to influence spermatogonial functions will become fully known, and the capacity to derive long-term cultures of SSCs and transplant the population to regenerate spermatogenesis and fertility will become a reality for higher order mammals. 

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Intro -- Preface -- Contents -- Contributors -- Part I: Spermatogenesis in Mammals -- 1: Organization of the Seminiferous Epithelium and the Cycle, and Morphometric Description of Spermatogonial Subtypes (Rodents and Primates) -- 1.1 Introduction -- 1.2 The Organization of the Seminiferous Epithelium -- 1.2.1 The Clonal Organization of the Seminiferous Epithelium -- 1.2.2 Timing of Germ Cell Development -- 1.2.3 Stages of the Cycle of the Seminiferous Epithelium -- 1.2.4 Wave of the Seminiferous Epithelium -- 1.3 Spermatogonial Cell Types -- 1.3.1 Non-primate Mammals -- 1.3.2 Primates -- 1.4 Cell Kinetics -- 1.4.1 Non-primates -- 1.4.2 Primates -- 1.5 Regulation of the Epithelial Cycle -- 1.6 The Spermatogonial Stem Cell Niche -- References -- Part II: Postnatal Development of the Spermatogonial Population -- 2: Transition of Prenatal Prospermatogonia to Postnatal Spermatogonia -- 2.1 Developmental Dynamics of the Prospermatogonia to Spermatogonia Transition -- 2.2 Heterogeneity Among Spermatogonia in the Neonatal Testis -- 2.3 Specification of Foundational Spermatogonial Stem Cells -- References -- 3: Setting the Stage: The First Round of Spermatogenesis -- 3.1 Initiation of Spermatogenesis -- 3.1.1 Initiation in Seasonal Breeders -- 3.1.2 Initiation in Nonseasonal Breeders -- 3.2 Germ Cell Kinetics During the First Wave of Spermatogenesis in Mice -- 3.3 Development of the Neonatal Spermatogonial Population -- 3.3.1 Timing and Regulation of Neonatal Spermatogonial Development -- 3.3.2 Establishment of Spermatogonial Cell Fate Begins in the Neonatal Testis -- 3.3.3 The First Wave of Spermatogenic Cells May Not Be Derived from SSCs -- 3.4 Development of the Somatic Cell Niche in the Mouse -- 3.5 Changes in Spermatogonial Gene Expression During the First Wave -- 3.6 Maintaining the Genome in First Wave Spermatogonia -- 3.7 Differences Between First and Subsequent Waves -- 3.8 Conclusions -- References -- Part III: Spermatogonial Stem Cells -- 4: Defining the Phenotype and Function of Mammalian Spermatogonial Stem Cells -- 4.1 Introduction -- 4.2 Functionally Defining SSCs -- 4.3 Can Xenotransplantation Quantify SSCs? -- 4.4 What Information About SSCs Can Be Gleaned from Marker Analysis? -- 4.5 Rigorously Defining the Phenotype of SSCs -- 4.6 The Short-List of Conserved, Bona Fide, Mammalian SSC Markers -- 4.7 The Quest to Purify SSCs -- 4.8 Phenotyping SSCs on a Background of Male Germline Heterogeneity -- 4.9 Conclusions -- References -- 5: Regulation of Spermatogonial Stem Cell Maintenance and  Self-Renewal -- 5.1 Introduction -- 5.2 Developmental Origins of the SSC Population -- 5.3 Models for Maintenance and Renewal of the SSC Pool -- 5.4 The SSC Niche -- 5.5 Tools to Study the SSC Population -- 5.5.1 Primary Spermatogonial Cultures -- 5.5.2 Cell Surface Markers -- 5.5.3 Spermatogonial Transplantation -- 5.5.4 Intracellular Markers -- 5.5.5 Reporter Transgenes -- 5.5.6 Lineage Tracing -- 5.6 M.