Telomeres and telomerase in aging, disease, and cancer : molecular mechanisms of adult stem cell ageing
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| 008 | 070619s2008 gw a b 001 0 eng c | |
| 010 | ▼a 2007931191 | |
| 015 | ▼a GBA773561 ▼2 bnb | |
| 020 | ▼a 9783540737087 (alk. paper) | |
| 020 | ▼a 3540737081 (alk. paper) | |
| 035 | ▼a (KERIS)REF000014850727 | |
| 040 | ▼a NLM ▼c NLM ▼d UKM ▼d BTCTA ▼d BAKER ▼d OHX ▼d DLC ▼d 211009 | |
| 042 | ▼a pcc | |
| 050 | 0 0 | ▼a QP86 ▼b .T34 2008 |
| 060 | 0 0 | ▼a 2007 M-065 |
| 060 | 1 0 | ▼a QU 470 ▼b T2774 2008 |
| 082 | 0 4 | ▼a 571.878 ▼2 22 |
| 090 | ▼a 571.878 ▼b T277 | |
| 245 | 0 0 | ▼a Telomeres and telomerase in aging, disease, and cancer : ▼b molecular mechanisms of adult stem cell ageing / ▼c K. Lenhard Rudolph, editor. |
| 260 | ▼a Berlin : ▼b Springer , ▼c c2008. | |
| 300 | ▼a xiv, 311 p. : ▼b ill. | |
| 504 | ▼a Includes bibliographical references and index. | |
| 650 | 0 | ▼a Aging ▼x Molecular aspects. |
| 650 | 0 | ▼a Telomere. |
| 650 | 0 | ▼a Telomerase. |
| 650 | 0 | ▼a Cancer ▼x Molecular aspects. |
| 650 | 1 2 | ▼a Telomere ▼x physiology. |
| 650 | 2 2 | ▼a Adult Stem Cells. |
| 650 | 2 2 | ▼a Aging ▼x genetics. |
| 650 | 2 2 | ▼a Cell Aging ▼x genetics. |
| 650 | 2 2 | ▼a Neoplasms ▼x genetics. |
| 650 | 2 2 | ▼a Telomerase ▼x physiology. |
| 700 | 1 | ▼a Rudolph, K. Lenhard. |
| 945 | ▼a KINS |
소장정보
| No. | 소장처 | 청구기호 | 등록번호 | 도서상태 | 반납예정일 | 예약 | 서비스 |
|---|---|---|---|---|---|---|---|
| No. 1 | 소장처 과학도서관/Sci-Info(2층서고)/ | 청구기호 571.878 T277 | 등록번호 121164328 (2회 대출) | 도서상태 대출가능 | 반납예정일 | 예약 | 서비스 |
컨텐츠정보
책소개
Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.
Twenty-five years after the disclosure of the telomeric DNA sequence and 22 years after the discovery of telomerase, it has become clear that telomeres and telomerase influence disease of human ageing including cancer. This book summarizes our current knowledge on the role of telomeres and telomerase in ageing, regeneration, and cancer with a special focus on ageing stem cells. Moreover, the book reviews current ef forts to target telomeres and telomerase for anticancer treatment or reg- erative therapies. 1. 1 Ageing The molecular analysis of ageing is an emerging research field that will have great impact on patients care, lifestyle, and on disease prevention in the human population worldwide. Major molecular mechanisms that influence the ageing process include (1) the accumulation of molecular damage affecting DNA and p- teins, (2) alterations in gene expression, including alterations in checkpoint responses, metabolic pathways, and developmental pathways, and (3) the decline in adult stem cell function. All these mechanisms lead to a decrease in organ main- nance and function, thus representing a major factor limiting the quality of life d- ing ageing. Moreover, the accumulation of molecular damage increases genetic alterations and the cancer risk during ageing. Indeed, increased age is the leading cause of cancer. Understanding the molecular basis of ageing will ultimately point to targets for novel therapies aiming to improve the function of cells and organs in the ageing organism, thus allowing increased vitality or what we think of as “healthy ageing.
New feature
The understanding of the molecular mechanisms underlying the ageing process is essential to improve quality of life and ‘health span’ in the growing populations of the elderly.
Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes experimental evidence and clinical data indicating that telomere dysfunction influences human ageing, diseases and cancer. In addition, the book describes our current knowledge on checkpoints that limit cellular lifespan (senescence) and survival (apoptosis, crisis) in response to telomere dysfunction.
A special focus of the book is on adult stem cells. There is emerging evidence that adult stem cell ageing impairs organismal fitness and survival and contributes to cancer formation (cancer stem cells). The book summarizes basic mechanisms of adult stem cell ageing. Moreover, the authors describe evidence that telomere dysfunction impairs stem cell function by inducing cell intrinsic checkpoints as well as environmental alterations.
All of these subjects are of great interest for ageing researchers, physicians and students and should provide a rational basis for beginning to identify molecular targets for novel therapies that aim to improve quality of life during ageing.
정보제공 :
목차
Telomere Shortening and Ageing.- Cellular versus Organismal Aging.- Telomere-Induced Senescence of Primary Cells.- Telomeres, Senescence, Oxidative Stress, and Heterogeneity.- Initiation of Genomic Instability, Cellular Senescence, and Organismal Aging by Dysfunctional Telomeres.- Telomerase Mutations and Premature Ageing in Humans.- Telomerase, Telomeres, and Stem Cell Aging.- Mechanisms of Stem Cell Ageing.- Senescence Signatures of Human Hematopoietic Stem Cells.- Telomere Shortening Induces Cell Intrinsic Checkpoints and Environmental Alterations Limiting Adult Stem Cell Function.- p16INK4a and Stem Cell Ageing: A Telomere-Independent Process?.- Telomerase as a Potential Regulator of Tissue Progenitor Cells.- Telomeres, DNA Damage and Cancer.- Telomere Shortening and Telomerase Activation during Cancer Formation.- Telomere Binding Proteins and Disease.- Therapeutic Targets.- Targeting Telomerase: Therapeutic Options for Cancer Treatment.- Werner Syndrome, Telomeres, and Stress Signaling: Implications for Future Therapies?.
정보제공 :