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Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk.

The book begins with the four basic principles of toxicology?dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field.

New topics in this edition include:

• The importance of dose?response
• Systems toxicology
• Food safety
• The humane use and care of animals
• Neurotoxicology

The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.

Based on the paradox that all things are poisonous at certain doses and the difference between poison and remedy is quantity, the determination of safe dosage forms the basis and focus of modern toxicology. Written by a team of experts, this sixth edition discusses basic toxicological principles, toxic agents, target organ toxicity, testing methods, and international regulatory requirements. New chapters cover advancements in nanotechnology and all chapters are updated to reflect the changing pace of research.

정보제공 :

The wissenschaften of toxicology : harming and helping through time / Richard W. Lane -- The use of toxicology in the regulatory process / Barbara D. Beck, Mara Seeley, and Edward J. Calabrese -- The dose-response : a fundamental concept in toxicology / Edward J. Calabrese -- Metabolism : a determinant of toxicity / Raymond A. Kemper, Mitchell E. Taub, and Matthew S. Bogdanffy -- Toxicokinetics / A. Roberts and Andrew Gordon Renwick -- Physiologically based pharmacokinetic and toxicokinetic models / Harvey J. Clewell III, Rebecca A. Clewell, and Melvin E. Andersen -- Toxicopanomics : applications of genomics, transcriptomics, proteomics, and lipidomics in predictive mechanistic toxicology / Julia Hoeng -- The toxicologic assessment of pharmaceutical and biotechnology products / Michael A. Dorato, Carl L. McMillian, and Tracy M. Williams -- Statistics for toxicologists / Shayne C. Gad -- The practice of exposure assessment / Dennis J. Paustenbach and Amy K. Madl --
Epidemiology for toxicologists / Geary W. Olsen, John L. Butenhoff, and Ralph R. Cook -- Principles of pathology for toxicology studies / Steven R. Frame, Peter C. Mann, and Jessica M. Caverly Rae -- The information infrastructure of toxicology / Philip Wexler, Fred Berman, Patricia Nance, Ann Parker, and Jacqueline Patterson -- Food safety / Claire Kruger, Dietz Conzi, Chada S. Reddy and A. Wallace Hayes -- Solvents and industrial hygiene / David L. Dahlstrom and John E. Snawder -- Crop protection chemicals : mechanism of action and hazard profiles / Charles B. Breckenridge and James T. Stevens -- Metals / Jan E. Hulla -- Ionizing radiation / Roger McClellian -- Plant and animal toxins / Frederick W. Oehme and Daniel E. Keyler -- The humane care and use of laboratory animals in toxicology research / Dale M. Cooper, Lisa Craig, Christopher N. Papagiannis, Duane W. Poage, Gregory W. Ruppert, and David G. Serota --
Validation and regulatory acceptance of new, revised, and alternative toxicological methods / William S. Stokes -- Acute toxicity and eye irritancy / Peter Chan and A. Wallace Hayes -- Genetic toxicology.