| 000 | 00000nam u2200205 a 4500 | |
| 001 | 000046029071 | |
| 005 | 20200602172209 | |
| 006 | m d | |
| 007 | cr | |
| 008 | 200522s2016 sz a ob 000 0 eng d | |
| 020 | ▼a 9783319396644 | |
| 040 | ▼a 211009 ▼c 211009 ▼d 211009 | |
| 050 | 4 | ▼a QR180-189.5 |
| 082 | 0 4 | ▼a 571.96 ▼2 23 |
| 084 | ▼a 571.96 ▼2 DDCK | |
| 090 | ▼a 571.96 | |
| 100 | 1 | ▼a Jankowski, Marek. |
| 245 | 1 0 | ▼a Interleukin-27 ▼h [electronic resource] : ▼b biological properties and clinical application / ▼c Marek Jankowski, Tomasz Wandtke. |
| 260 | ▼a Cham : ▼b Springer International Publishing : ▼b Imprint: Springer, ▼c 2016. | |
| 300 | ▼a 1 online resource (vi, 86 p.) : ▼b ill. (some col.). | |
| 490 | 1 | ▼a SpringerBriefs in immunology, ▼x 2194-2773 |
| 500 | ▼a Title from e-Book title page. | |
| 504 | ▼a Includes bibliographical references. | |
| 505 | 0 | ▼a IL-27: Structure, Regulation and Variability -- IL-27: A Key Player in Immune Regulation -- IL-27 in Health and Disease. |
| 520 | ▼a This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike. | |
| 530 | ▼a Issued also as a book. | |
| 538 | ▼a Mode of access: World Wide Web. | |
| 650 | 0 | ▼a Medicine. |
| 650 | 0 | ▼a Interleukins. |
| 700 | 1 | ▼a Wandtke, Tomasz. |
| 830 | 0 | ▼a SpringerBriefs in immunology. |
| 856 | 4 0 | ▼u https://oca.korea.ac.kr/link.n2s?url=http://dx.doi.org/10.1007/978-3-319-39664-4 |
| 945 | ▼a KLPA | |
| 991 | ▼a E-Book(소장) |
소장정보
| No. | 소장처 | 청구기호 | 등록번호 | 도서상태 | 반납예정일 | 예약 | 서비스 |
|---|---|---|---|---|---|---|---|
| No. 1 | 소장처 중앙도서관/e-Book 컬렉션/ | 청구기호 CR 571.96 | 등록번호 E14022631 | 도서상태 대출불가(열람가능) | 반납예정일 | 예약 | 서비스 |