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Biotechnology has been labelled as one of the key technologies of the last two decades of the 20th Century, offering boundless solutions to problems ranging from food and agricultural production to pharmaceutical and medical applications, as well as environmental and bioremediation problems. Biological processes, however, are complex and the prevailing mechanisms are either unknown or poorly understood. This means that adequate techniques for data acquisition and analysis, leading to appropriate modeling and simulation packages that can be superimposed on the engineering principles, need to be routine tools for future biotechnologists. The present volume presents a masterly summary of the most recent work in the field, covering: instrumentation systems; enzyme technology; environmental biotechnology; food applications; and metabolic engineering.

Proceedings of the NATO Advanced Study Institute on `Use of Computer and Informatic Systems in Bioprocess Engineering', Ofir, Portugal, May 18-29, 1992

Biotechnology has been labelled as one of the key technologies of the last two decades of the 20th Century, offering boundless solutions to problems ranging from food and agricultural production to pharmaceutical and medical applications, as well as environmental and bioremediation problems. Biological processes, however, are complex and the prevailing mechanisms are either unknown or poorly understood. This means that adequate techniques for data acquisition and analysis, leading to appropriate modeling and simulation packages that can be superimposed on the engineering principles, need to be routine tools for future biotechnologists. The present volume presents a masterly summary of the most recent work in the field, covering: instrumentation systems; enzyme technology; environmental biotechnology; food applications; and metabolic engineering.

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Preface. Part 1: Instrumentation Systems. Computer-Based Studies on Bioprocess Engineering: I-Tools for Process Analysis; S. Feyo de Azevedo, et al. Computer-Based Studies on Bioprocess Engineering: II-Tools for Process Operation; S. Feyo de Azevedo, et al. Multivariable Control of a Continuous Culture; P.A. Gostomski, et al. Steady States in Continuous Culture; H.R. Bungay. Introduction to Artificial Intelligence; H.R. Bungay. Nonlinear Oscillations in Bioreaction Systems; R.Y.K. Yang, J. Su. Bioreactor Instrumentation and Biosensors; K. Schugerl. Bioreactors for Improved Process Performance; K. Schugerl. Bioreactor Fault Detection Using Data Reconciliation; J.J. Prior and C.L. Cooney. The Design Approach of Multiproduct Plants; J. Mata-Alvarez, C. Rolz. Strategies for Bioreactor Scale-Up; F. Mavituna. Statistical Design and Analysis of Experiments; C.E. Rolz. Simulation of a Complex Biotechnological Process Using an Object-Oriented Knowledge-Based System; M. Polakovic, C.F. Mandenius. Part 2: Enzyme Technology. The Implication of Ph on the Design of an Enzymatic Reactor for Penicillin Hydrolysis; A. Gomez-Aguirre, et al. Simulation of Batch Enzyme Reactors; A. Lopez-Munguia. Modeling of Membrane Bioreactors; D.M.F. Prazeres, et al. Membrane Bioreactor with Immobilized Lipase: Modelling and Computational Considerations; F.X. Malcata. Protein Extraction by Reversed Micellar Systems; M.R. Aires-Barros, J.M.S. Cabral. Part 3: Environmental Biotechnology. Role of Cyanide on Polycyclic Aromatic Hydrocarbon Degradation in Manufactured Gas Plant Soils; L.S. Clesceri, et al. Biomass Refining; H.R. Bungay. Anaerobic Methane Fermentation in a Plug-Flow Reactor Treating OrganicWastes; J. Mata-Alvarez, P. Llabres-Luengo. Activated Sludge; H.R. Bungay. Biotechnology and the Environment; A. Moser. Part 4: Food Applications. An Efficient Computer Programme for the Simulation of Food Freezing Operations; A.M. Figueiredo, A.M. Sereno. Modelling and Simulation of Convective Green-Pea Drying; G.L. Medeiros, A.M. Sereno. Part 5: Metabolic Engineering. Modelling of the Baculovirus Infection Process in Insect&endash;Cell Reactor Configurations; C.D. De Gooijer, et al. Use of Fed-Batch Operation to Improve Secondary Metabolite Production; K.K. Wallace, et al. Bioreactor Design for Animal Cell Culture: With Special Reference to Mass Transfer; R.E. Spier. General Methodology in Bioprocess Engineering; A. Moser. Industrial Scale Antibiotic Production: Process Kinetic Analysis and Process Design; A. Moser. Oxygen Transfer and Microbial Growth; A. Moser. Classroom Adaptation of Escherichia Coli Single Cell Model; G.J. Stanlake, M.L. Shuler. Kinetics of Continuous Microbial Culture: Plug-Flow, Chemostat, Turbidostat and Fed-Batch Principles; E.J. VanDamme, M. Van Speybroeck. A Spreadsheet Simulation of a Differential Reactor for Estimating Kinetic Constants; J. Mata-Alvarez, P. Clapes. Production of Fuel Alcohols by Fermentation: Engineering and Physiological Basis for Improving Processes; G. Goma, et al. Index.

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