Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells [electronic resource] : mathematical modeling and experimental observations
| 000 | 00000nam u2200205 a 4500 | |
| 001 | 000046035844 | |
| 005 | 20200720131347 | |
| 006 | m d | |
| 007 | cr | |
| 008 | 200702s2015 sz a ob 000 0 eng d | |
| 020 | ▼a 9783319149622 | |
| 040 | ▼a 211009 ▼c 211009 ▼d 211009 | |
| 050 | 4 | ▼a QL963.5 |
| 082 | 0 4 | ▼a 571.8636 ▼2 23 |
| 084 | ▼a 571.8636 ▼2 DDCK | |
| 090 | ▼a 571.8636 | |
| 100 | 1 | ▼a Tavassoly, Iman. ▼e author. |
| 245 | 1 0 | ▼a Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells ▼h [electronic resource] : ▼b mathematical modeling and experimental observations / ▼c Iman Tavassoly. |
| 260 | ▼a Cham : ▼b Springer International Publishing : ▼b Imprint: Springer, ▼c 2015. | |
| 300 | ▼a 1 online resource (xxi, 79 p.) : ▼b ill. (some col.). | |
| 490 | 1 | ▼a Springer theses, recognizing outstanding Ph.D. research, ▼x 2190-5053 |
| 500 | ▼a Title from e-Book title page. | |
| 504 | ▼a Includes bibliographical references. | |
| 505 | 0 | ▼a Introduction -- Mathematical Modeling of the Interplay of Autophagy and Apoptosis -- An Experimental Framework to Study the Dynamics of Autophagic Response -- Conclusions -- Source Code. |
| 520 | ▼a This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells. | |
| 530 | ▼a Issued also as a book. | |
| 538 | ▼a Mode of access: World Wide Web. | |
| 650 | 0 | ▼a Cell determination ▼x Mathematical models. |
| 650 | 0 | ▼a Apoptosis ▼x Mathematical models. |
| 650 | 0 | ▼a Cell determination ▼x Observations. |
| 650 | 0 | ▼a Apoptosis ▼x Observations. |
| 650 | 0 | ▼a Cancer cells. |
| 830 | 0 | ▼a Springer theses, recognizing outstanding Ph.D. research. |
| 856 | 4 0 | ▼u https://oca.korea.ac.kr/link.n2s?url=http://dx.doi.org/10.1007/978-3-319-14962-2 |
| 945 | ▼a KLPA | |
| 991 | ▼a E-Book(소장) |
소장정보
| No. | 소장처 | 청구기호 | 등록번호 | 도서상태 | 반납예정일 | 예약 | 서비스 |
|---|---|---|---|---|---|---|---|
| No. 1 | 소장처 중앙도서관/e-Book 컬렉션/ | 청구기호 CR 571.8636 | 등록번호 E14026923 | 도서상태 대출불가(열람가능) | 반납예정일 | 예약 | 서비스 |