CONTENTS
Introduction = 1
General = 2
Developments in biological standardization = 2
Global project on quality assurance of plasma-derived medicinal products and plasma-fractionation activities = 3
Independent review of WHO'S remit and activities in the field of biologicals = 3
Reverse transcriptase associated with avian cells = 5
Comments from users of recommendations(requirements) and guidelines published by WHO and international reference materials = 6
International nonproprietary names = 7
International guidelines, recommendations and other matters related to the manufacture and quality control of biologicals = 7
Recommendations for Haemophilus influenzae type b conjugate vaccine = 7
Recommendations for poliomyelitis vaccine(oral) = 8
Guidelines for the production and control of the acellular pertussis component of monovalent or combined vaccines = 9
List of recommendations for biological substances and other sets of recommendations : proposed new format, electronic publication and proposed discontinuations = 11
Work in progress and proposed new work on recommendations and guidelines = 12
International reference materials = 13
Review of existing reference materials : proposed database and electronic publication = 13
Proposals for replacement or discontinuation = 14
Work in progress and proposed new work : general report = 16
WHO consultation on review and replacement of International Standards for blood-grouping reagents = 17
Working group on reference preparations for testing diagnostic kits used for detection of hepatitis B and C and human immunodeficiency virus in blood screening = 17
Standardization of diagnostic tests for prions = 18
Antibodies = 19
Clostridium perfringens beta antitoxin, equine = 19
Anti-hepatitis A immunoglobulin and serum, human = 19
Antigens and related substances = 19
Pertussis vaccine : third International Standard = 19
Blood products and related substances = 20
Blood coagulation factor Ⅶ concentrate = 20
Blood coagulation factor Ⅷ concentrate = 21
Blood coagulation factor Ⅷ and von Willebrand factor in plasma = 21
Blood coagulation factor Ⅸa, human = 21
Haemoglobincyanide = 22
WHO informal consultation on standardization of unfractionated heparin and proposed fifth International Standard for Unfractionated Heparin = 22
Plasmin = 23
Cytokines = 23
WHO informal consultation on cytokine standards = 23
Activin A, human, recombinant = 24
lnterleukin-2 soluble receptor = 24
Sex hormone binding globulin = 25
Miscellaneous = 25
Botulinum type A toxin = 25
Annex 1 : Recommendations for the production and control of Haemophilus influenzae type b conjugate vaccines = 27
Annex 2 : 1990 Requirements for poliomyelitis vaccine(oral)(Addendum 1998) = 61
Annex 3 : Recommendations and guidelines for biological substances used in medicine and other documents = 67
Annex 4 : International Biological Reference Preparations = 71
Annex 5 : Biological substances : International Standards and Reference Reagents = 101
Annex 6 : Corrigendum : International Standard for Insulin-like Growth Factor 1 = 103
