INTRODUCTION TO TISSUE ENGINEERING
1. The History and Scope of Tissue Engineering
Joseph P. Vacanti and Charles A. Vacanti
2. The Challenge of Imitating Nature
Robert M. Nerem
3. Moving into the Clinic
Alan J. Russell and Timothy Bertram
4. Future Perspectives
Mark E. Furth and Anthony Atala
PART ONE: THE BASIS OF GROWTH AND DIFFERENTIATION
5. Molecular Biology of the Cell
Jonathan Slack
6. Organization of Cells into Higher-Ordered Structures
Jon D. Ahlstrom and Carol A. Erickson
7. Dynamics of Cell-ECM Interactions
M. Petreaca and Manuela Martins-Green
8. Matrix Molecules and Their Ligands
Bjorn Reino Olsen
9. Morphogenesis and Tissue Engineering
A.H. Reddi
10. Gene Expression, Cell Determination and Differentiation
William Nikovits, Jr. and Frank E. Stockdale
PART TWO: IN VITRO CONTROL OF TISSUE DEVELOPMENT
11. Engineering Functional Tissues
Lisa E. Freed and Farshid Guilak
12. Principles of Tissue Culture and Bioreactor Design
R.I. Freshney, B. Obradovic, W. Grayson, C. Cannizzaro and Gordana Vunjak-Novakovic
13. Regulation of Cell Behavior by Extracellular Proteins
Amy Bradshaw and E. Helene Sage
14. Growth Factors
Thomas F. Deuel and Yunchao Chang
15. Mechanochemical Control of Cell Fate Switching
Donald E. Ingber
PART THREE: IN VIVO SYNTHESIS OF TISSUES AND ORGANS
16. In Vivo Synthesis of Tissues and Organs
Brendan A. Harley and Ioannis V. Yannas
PART FOUR: MODELS FOR TISSUE ENGINEERING
17. Models as Precursors for Prosthetic Devices
Eugene Bell
18. Quantitative Aspects
Alan J. Grodzinsky, Roger D. Kamm, and Douglas A. Lauffenburger
PART FIVE: BIOMATERIALS IN TISSUE ENGINEERING
19. Micro-Scale Patterning of Cells and Their Environment
Xingyu Jiang, Shuichi Takayama, Robert G. Chapman, Ravi S. Kane and George M. Whitesides
20. Cell Interactions with Polymers
W. Mark Saltzman and Themis R. Kyriakides
21. Matrix Effects
Jeffrey A. Hubbell
22. Polymer Scaffold Fabrication
Matthew B. Murphy and Antonios G. Mikos
23. Biodegradable Polymers
James M. Pachence, Michael P. Bohrer and Joachim Kohn
24. Micro- and Nanofabricated Scaffolds
Christopher J. Bettinger, Jeffrey T. Borenstein and Robert Langer
25. Three-Dimensional Scaffolds
Ying Luo, George Engelmayr, Debra T. Auguste, Lino da Silva Ferreira, Jeffrey M. Karp, Rajiv Saigal and Robert Langer
PART SIX: TRANSPLANTATION OF ENGINEERED CELLS AND TISSUES
26. Tissue Engineering and Transplantation in the Fetus
Dario O. Fauza
27. Immunomodulation
Denise L. Faustman
28. Immunoisolation
Beth A. Zielinski and Michael J. Lysaght
29. Engineering Challenges in Immunobarrier Device Development
Amy S. Lewis and Clark K. Colton
PART SEVEN: STEM CELLS
30. Embryonic Stem Cells
Alan Trounson
31. Adult Epithelial Tissue Stem Cells
Christopher S. Potten and James W. Wilson
32. Embryonic Stem Cells as a Cell Source for Tissue Engineering
Ali Khademhosseini, Jeffrey M. Karp, Sharon Gerecht, Lino Ferreira, Gordana Vunjak-Novakovic and Robert Langer
33. Postnatal Stem Cells
Pamela Gehron Robey and Paulo Bianco
PART EIGHT: GENE THERAPY
34. Gene Therapy
Ronald G. Crystal and Stefan Worgall
35. Gene Delivery into Cells and Tissues
Ales Prokop and Jeffrey M. Davidson
PART NINE: BREAST
36. Breast Reconstruction
Lamont Cathey, Kuen Yong Lee, Walter D. Holder, David J. Mooney and Craig R. Halberstadt
PART TEN: CARDIOVASCULAR SYSTEM
37. Progenitor Cells and Cardiac Homeostasis
Annarosa Leri, Toru Hosoda, Marcello Rota, Claudia Bearzi, Konrad Urbanek, Roberto Bolli, Jan Kejstura and Piero Anversa
38. Cardiac-Tissue Engineering
M. Radisic, H. Park and G. Vunjak-Novakovic
39. Blood Vessels
Luke Brewster, Eric M. Brey and Howard P. Greisler
40. Heart Valves
Peter Marc Fong, Jason Park and Christopher Kane Breuer
PART ELEVEN: ENDOCRINOLOGY AND METABOLISM
41. Generation of Islets from Stem Cells
Bernat Soria, Abdelkrim Hmadcha, Francisco J. Bedoya and Juan R. Tejedo
42. Bioartificial Pancreas
Athanassios Sambanis
43. Engineering Pancreatic Beta-Cells
Hee-Sook Jun and Ji-Won Yoon
44. Thymus and Parathyroid Organogenesis
Craig Scott Nowell, Ellen Richie, Nancy Ruth Manley and Catherine Clare Blackburn
PART TWELVE: GASTROINTESTINAL SYSTEM
45. Adult Stem Cells in Normal Gastrointestinal Function and Inflammatory Disease
Mairi Brittan and Nicholas A. Wright
46. Alimentary Tract
Shaun M. Kunisaki and Joseph Vacanti
47. Liver Stem Cells
Eric Lagasse
48. Liver
Gregory H. Underhill, Salman R. Khetani, Alice A. Chen and Sangeeta N. Bhatia
PART THIRTEEN: HEMATOPOIETIC SYSTEM
49. Hematopoietic Stem Cells
Malcolm A.S. Moore
50. Red Blood Cell Substitutes
Thomas M. S. Chang
51. Lymphoid Cells
Una Chen
PART FOURTEEN: KIDNEY AND GENITOURINARY SYSTEM
52. Stem Cells in Kidney Development and Regeneration
Gregory R. Dressler
53. Renal Replacement Devices
H. David Humes
54. Genitourinary System
Anthony Atala
PART FIFTEEN: MUSCULOSKELETAL SYSTEM
55. Mesenchymal Stem Cells
Faye H. Chen, Lin Song, Robert L. Mauck, Wan-Ju Li and Rocky S. Tuan
56. Bone Regeneration
Chantal E. Holy, F. Jerry Volenec, Jeffrey Geesin and Scott P. Bruder
57. Bone and Cartilage Reconstruction
Wei Liu, Wenjie Zhang and Yilin Cao
58. Regeneration and Replacement of the Intervertebral Disc
Lori A. Setton, Lawrence J. Bonassar and Koichi Masuda
59. Articular Cartilage Injury
Joseph A. Buckwalter, J.L. Marsh, T. Brown, A. Amendola and J.A. Martin
60. Tendons and Ligaments
Francine Goulet, Lucie Germain, A. Robin Poole and Francois A. Auger
61. Mechanosensory Mechanisms in Bone
Upma Sharma, Antonios G. Mikos and Stephen C. Cowin
62. Skeletal-Tissue Engineering
Matthew D. Kwan, Derrick C. Wan and Michael T. Longaker
PART SIXTEEN: NERVOUS SYSTEM
63. Neural Stem Cells
Lorenz Studer
64. Brain Implants
Lars U. Wahlberg
65. Spinal Cord Injury
John W. McDonald and Daniel Becker
66. Protection and Repair of Audition
Richard Altschuler, Yehoash Raphael, David C. Martin, Jochen Schacht, David J. Anderson and Josef M. Miller
PART SEVENTEEN: OPHTHALMIC APPLICATIONS
67. Stem Cells in the Eye
Michael E. Boulton, Julie Albon and Maria B. Grant
68. Corneal-Tissue Replacement
Jeffrey W. Ruberti, James D. Zieske and Vickery Trinkaus-Randall
69. Vision Enhancement Systems
Gislin Dagnelie
PART EIGHTEEN: ORAL/DENTAL APPLICATIONS
70. Biological Tooth Replacement and Repair
Anthony J. (Tony) Smith and Paul T. Sharpe
71. Oral and Maxillofacial Surgery
Simon Young, Kyriacos A. Athanasiou, Antonios G. Mikos and Mark Eu-Kien Wong
72. Periodontal-Tissue Engineering
Hai Zhang, Hanson K. Fong, William V. Giannobile and Martha J. Somerman
PART NINETEEN: RESPIRATORY SYSTEM
73. Progenitor Cells in the Respiratory System
Valerie Besnard and Jeffrey A. Whitsett
74. Lungs
Anne E. Bishop and Julia A. Polak
PART TWENTY: SKIN
75. Cutaneous Stem Cells
George Cotsarelis
76. Wound Repair
Kaustabh Ghosh and Richard A.F. Clark
77. Bioengineered Skin Constructs
Vincent Falanga and Katie Faria
PART TWENTY-ONE: CLINICAL EXPERIENCE
78.Current State of Clinical Application
Shaun M. Kunisaki and Dario O. Fauza
79. Tissue-Engineered Skin Products
Jonathan Mansbridge
80. Tissue-Engineered Cartilage Products
David W. Levine
81. Tissue-Engineered Bone Products
John F. Kay
82. Tissue-Engineered Cardiovascular Products
Thomas Eschenhagen, Herrmann Reichenspurner and Wolfmram-Hubertus Zimmermann
83. Tissue-Engineered Organs
Steve J. Hodges and Anthony Atala
PART TWENTY-TWO: REGULATION AND ETHICS
84. The Tissue-Engineering Industry
Michael J. Lysaght, Elizabeth Deweerd and Ana Jaklenec
85. The Regulatory Path From Concept to Market
Kiki B. Hellman
86. Ethical Issues
Laurie Zoloth
Epilogue
Joseph P. Vacanti
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