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This comprehensive resource details the history, methodology and development of research into psychoneuroimmunology, balancing it with meticulous coverage of both the clinical aspects and practical applications of the subject.

• A much-needed reference including overviews of key advances in the field
• Discusses how psychoneuroimmunological research is conceived and executed
• Includes contributions from a wealth of experts in the field
• Forward by Robert Ader and Nicholas Cohen, founders of the discipline
• Authoritative and interdisciplinary in scope - integrating biological and behavioral science

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The interdisciplinary nature of the contributions reflects the fact that the subject is a multifaceted field of research integrating the traditionally separate subjects of biological and behavioral science. Psychoneuroimmunology attains a realistic appreciation of the interplay between different biological systems as they collectively maintain health and combat environmental challenges to health. Background material is balanced by a detailed assessment of emerging topics in psychoneuroimmunological research that focuses on the clinical and practical implications of findings from empirical studies on both humans and animals. While specialist readers will appreciate the coverage of progress made in psychoneuroimmunology, newcomers will gain much from its informed and accessible introduction to the field, as well as its exploration of a variety of methodological approaches.

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Preface ix
 Alexander W. Kusnecov and Hymie Anisman
 
Foreword xiii
 Robert Ader and Nicholas Cohen
 
List of Contributors xvii
 
1 Basic Principles in Immunology: Relevance for Studies in Psychoneuroimmunology 1
 Sarah M. Clark, Kerry C. Michael, Achsah D. Keegan, and Leonardo H. Tonelli
 
2 Innervation of the Immune System 24
 Denise L. Bellinger, Dwight M. Nance, and Dianne Lorton
 
3 In Vitro and In Vivo Assessment of Immune System Modulation of Brain Function and Neurochemistry 73
 Michael O. Poulter and Zul Merali
 
4 Control and Contributions of the Blood–Brain Barriers to Cytokine Levels in the CNS 88
 William A. Banks
 
5 The Immune–Neuroendocrine Network in Health and Disease 99
 Adriana del Rey and Hugo O. Besedovsky
 
6 Neural Functions of Hematopoietic-derived Cells 120
 Noel C. Derecki and Jonathan Kipnis
 
7 Immunoregulatory Neuropeptides 144
 Doina Ganea and Mario Skarica
 
8 Regulation of Immune Cell Activity by Norepinephrine and Beta2-Adrenergic Receptor Engagement 161
 Caroline J. Padro, Jaclyn W. McAlees, and Virginia M. Sanders
 
9 Immune-to-Brain Communication in Pain: Historical Perspectives, New Directions 176
 Peter M. Grace, Linda R. Watkins, and Mark R. Hutchinson
 
10 Stress and Neuroendocrine–Immune Interaction: A Therapeutic Role for Beta-endorphin 198
 Olivia Wynne and Dipak K. Sarkar
 
11 Assessing Neuroendocrine-Mediated Modulation of Immunity to Infection in Animals: Caveats and Methodological Issues 212
 Jodi L. Yorty and Robert H. Bonneau
 
12 Approaches to Assessing Stressor-Induced Cytokine and Endocrine Changes in Humans 234
 Kim Matheson and Hymie Anisman
 
13 Stress and Immune Function in Humans: A Life-Course Perspective 251
 Jan A. Moynihan, Kathi L. Heffner, Mary T. Caserta, and Thomas G. O'Connor
 
14 Predicting Health: The Role of the Early-Life Environment 266
 Luba Sominsky, Adam K. Walker, and Deborah M. Hodgson
 
15 Microglia and Neurodevelopment: Programming of Cognition throughout the Lifespan 296
 Jaclyn M. Schwarz and Staci D. Bilbo
 
16 Aging and the Immune System 313
 Ashley M. Fenn, Angela W. Corona, and Jonathan P. Godbout
 
17 Peripheral Pro-inflammatory Cytokines and Cognitive Aging: The Role of Metabolic Risk 330
 Alvin Lim and Anna Marsland
 
18 Immune Stimulation and Cognitive Function: Defining the Deficits and Avoiding the Pitfalls 347
 Colm Cunningham
 
19 The Role of NF-kB in Behavioral and Neural Plasticity 365
 Elyse M. Mallimo and Alexander W. Kusnecov
 
20 Inflammatory Roads to Neurodegeneration: A Focus on Parkinson's and Alzheimer's Disease 393
 Shawn Hayley and Darcy Litteljohn
 
21 The Psychotic Face of the Immune System: Inflammation and Schizophrenia 411
 Urs Meyer
 
22 Neuroimmune Mechanisms in Autism 425
 Veronica M. Miller, Rachael Racine, and Steven S. Zalcman
 
23 Depression, Inflammation and Tryptophan Metabolism 448
 Robert H. McCusker, Annemieke Kavelaars, Cobi J. Heijnen, Robert Dantzer, and Keith W. Kelley
 
24 An Inflammatory Perspective of Stress and Human Depressive Disorder 469
 M.-C. Audet, S. Jacobson-Pick, R. McQuaid, and Hymie Anisman
 
25 Interaction Between Immune and Energy-Balance Signals in the Regulation of Feeding and Metabolism 488
 Alfonso Abizaid, Giamal Luheshi, and Barbara C. Woodside
 
26 Psychoneuroimmunological Processes in Coronary Artery Disease and Heart Failure 504
 Willem J. Kop and Paula M.C. Mommersteeg
 
Index 525

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