상세정보

This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.

This book is an introductory text in neuroendocrinology for undergraduate students.

정보제공 :

CONTENTS
Preface = xiii
Acknowledgements = xv
Illustration credits = xvi
List of abbreviations = xix
1. Classification of chemical messengers = 1
 1.1 Hormones, the brain and behavior = 1
 1.2 The body's three communication systems = 3
 1.3 Methods of communication between cells = 5
 1.4 Types of chemical messenger = 6
 1.5 Neuroregulators : neuromodulators and neuropeptides = 13
 1.6 Summary = 15
2. The endocrine glands and their hormones = 19
 2.1 The endocrine glands = 19
 2.2 The hormones of the endocrine glands = 20
 2.3 Summary = 27
3. The pituitary gland and its hormones = 30
 3.1 The pituitary gland = 30
 3.2 The hormones of the pituitary gland = 33
 3.3 The endorphins = 36
 3.4 Pituitary hormones in the brain = 37
 3.5 Summary = 37
4. The hypothalamic hormones = 40
 4.1 The functions of the hypothalamus = 40
 4.2 Hypothalamic neurosecretory cells = 41
 4.3 The neuroendocrine transducer concept = 44
 4.4 The hypothalamic hypophysiotropic hormones = 45
 4.5 Complexities of hypothalamic-pituitary interactions = 50
 4.6 Summary = 52
5. Neurotransmitters = 56
 5.1 Categories of neurotransmitters = 57
 5.2 The nerve cell and the synapse = 60
 5.3 Neurotransmitter biosynthesis and storage = 61
 5.4 The release of neurotransmitters and their action at receptors = 65
 5.5 Receptors for neurotransmitters = 65
 5.6 Deactivation of neurotransmitters = 69
 5.7 Neurotransmitter pathways = 70
 5.8 Drugs influencing neurotransmitters and their receptors = 74
 5.9 Nutrients modifying neurotransmitter levels = 78
 5.10 The divisions of the nervous system = 79
 5.l1 Summary = 84
6. Neurotransmitter control of hypothalamic, pituitary and other hormones = 88
 6.1 The cascade of chemical messengers = 88
 6.2 Neural control of hypothalamic neurosecretory cells = 90
 6.3 Neurotransmitter regulation of adenohypophyseal hormones = 93
 6.4 Neurotransmitter regulation of neurohypophyseal hormones = 101
 6.5 Electrophysiology of neurosecretory cells = 102
 6.6 Neurotransmitter regulation of other endocrine glands = 103
 6.7 Complications in the study of the neurotransmitter control of hypothalamic hormone release = 105
 6.8 Neuroendocrine correlates of psychiatric disorders and psychotropic drug treatment of these disorders = 107
 6.9 Summary = 108
7. Regulation of hormone synthesis, storage, release, transport and deactivation = 113
 7.1 The chemical structure of hormones = 113
 7.2 Hormone synthesis = 115
 7.3 Storage and intracellular transport of peptide hormones = 119
 7.4 Hormone release = 120
 7.5 Hormone transport = 120
 7.6 Deactivation of hormones = 122
 7.7 Methodology for neuroendocrine research = 123
 7.8 Summary = 124
8. Regulation of hormone levels in the bloodstream = 127
 8.1 Measuring hormone levels = 127
 8.2 Mechanisms regulating hormone levels = 131
 8.3 Hormonal modulation of neurotransmitter release = 139
 8.4 The cascade of chemical messengers revisited = 139
 8.5 When hormone regulatory mechanisms fail = 141
 8.6 Summary = 142
9. Steroid and thyroid hormone receptors = 147
 9.1 The intracellular receptor superfamily = 147
 9.2 How are hormone target cells identified? = 148
 9.3 How are steroid hormone target cells differentiated from non-target cells? = 149
 9.4 Action of steroid hormones at their receptors = 151
 9.5 Measurement and regulation of hormone receptor numbers = 152
 9.6 Gonadal steroid hormone target cells in the brain = 154
 9.7 Adrenal steroid hormone target cells in the brain = 161
 9.8 Genomic and non-genomic actions of steroid hormones at nerve cells = 165
 9.9 Functions of steroid hormone modulation of nerve cells = 175
 9.10 Thyroid hormone receptors = 180
 9.11 Summary = 182
10. Receptors for peptide hormones, neuropeptides and neurotransmitters = 191
 10.1 Membrane receptors = 192
 10.2 Signal transduction by G-proteins = 195
 10.3 Second messenger systems = 199
 10.4 Interactions among second messenger systems = 206
 10.5 Signal amplification = 207
 10.6 Second messengers in the brain and nervous system = 208
 10.7 Comparison of steroid and peptide hormone actions at their target cells = 213
 10.8 Summary = 251
11. Neuropeptides Ⅰ : classification, synthesis and colocalization with classical neurotransmitters = 221
 11.1 Classification of the neuropeptides = 221
 11.2 Synthesis, storage, release and deactivation of neuropeptides = 223
 11.3 Exploring the relationships between neuropeptides, neurotransmitters and hormones = 228
 11.4 Coexistence (Colocalization) of neurotransmitters and neuropeptides = 235
 11.5 Localization of neuropeptide cell bodies and pathways in the brain = 238
 11.6 Neuropeptide receptors and second messenger systems = 244
 11.7 Neuropeptides and the blood-brain barrier = 246
 11.8 Summary = 248
12. Neuropeptides Ⅱ : neuropeptide function = 266
 12.1 Neurotransmitter and neuromodulator actions of neuropeptides： a dichotomy or a continuum? = 266
 12.2 Neurotransmitter actions of neuropeptides = 270
 12.3 Neuromodulator actions of neuropeptides = 272
 12.4 Effects of neuropeptides on the neuroendocrine system = 279
 12.5 Visceral, cognitive and behavioral effects of neuropeptides = 284
 12.6 Summary = 298
13. Cytokines and the interaction between the neuroendocrine and immune systems = 302
 13.1 The cells of the immune system = 302
 13.2 The thymus gland and its hormones = 305
 13.3 Cyokines : the messengers of the immune system = 307
 13.4 The functions of cytokines in the immune and hematopoietic systems = 312
 13.5 Effects of cytokines and other 'immunomodulators' on the brain and neuroendocrine system = 316
 13.6 Neural and endocrine regulation of the immune system = 324
 13.7 Hypothalamic integration of the neuroendocrine―immune system = 333
 13.8 Summary = 335
14. Methods for the study of behavioral neuroendocrinology = 346
 14.1 Behavioral bioassays = 374
 14.2 Correlational studies of hormonal and behavioral changes = 348
 14.3 Experimental studies.Ⅰ. Behavioral responses to neuroendocrine manipulation = 352
 14.4 Experimental studies.Ⅱ. Neuroendocrine responses to environmental behavioral and cognitive stimuli = 360
 14.5 Neural and genomic mechanisms mediating neuroendocrine behavior interactions = 368
 14.6 Confounding variables in behavioral neuroendocrinology research = 376
 14.7 Summary = 385
15. An overview of behavioral neuroendocrinology : present, future and past = 395
 15.1 The aim of this book = 395
 15.2 The history of behavioral neuroendocrinology = 397
Appendix : Journals in endocrinology, neuroendocrinology, psychoneuroimmunology and behavioral endocrinology = 400
Index = 402